Agenda

All times are Eastern Daylight Time.

Welcome to Day 1
9:50 a.m. - 10:00 a.m. Welcome and Day 1 Introduction
Terry Watnick, M.D., Professor of Medicine, Joan B. and John H. Sadler Professor in Nephrology, and Principal Investigator, PKD RRC Coordinating Site, University of Maryland School of Medicine
10:00 a.m. - 11:15 a.m. Session 1: Novel Aspects of Polycystin Function and Signaling
 

Session Chairs: Markus Delling, Ph.D., Assistant Professor, University of California, San Francisco
Francisco Altamirano, Ph.D., Assistant Professor, Houston Methodist
10:00 a.m. - 10:20 a.m. The Energetic Landscape of Opening the Polycystin Pore
Paul DeCaen, Ph.D., Assistant Professor, Northwestern University
10:20 a.m. - 10:25 a.m. Questions
10:25 a.m. - 10:45 a.m. Lessons from the Adhesion G-Protein-coupled Receptors Field for PKDs
Demet Araç, Ph.D., Associate Professor, The University of Chicago
10:45 a.m. - 10:50 a.m. Questions
10:50 a.m. - 11:10 a.m. Blood Pressure Regulation by Vascular Polycystin Proteins
Jonathan Jaggar, Ph.D., Professor, The University of Tennessee Health Science Center
11:10 a.m. - 11:15 a.m. Questions
11:15 a.m. - 11:20 a.m. Break
11:20 a.m. - 12:35 p.m. Session 2: Latest Advances in Pediatric Polycystic Kidney Disease (PKD)
 

Session Chairs: Melissa Cadnapaphornchai, M.D., Pediatric Nephrology, Rocky Mountain Pediatric Kidney Center
Ashima Gulati, M.D., Ph.D., Assistant Professor, Children's National
11:20 a.m. - 11:40 a.m. Autosomal Recessive PKD: Natural History Insights from the ARegPKD Study
Max Liebau, M.D., Head of Translational Experimental Pediatric Nephrology, University of Cologne, Germany
11:40 a.m. - 11:45 a.m. Questions
11:45 a.m. - 12:05 p.m. New Therapeutic Concepts Form Nephronophthisis and Related Ciliopathies
Sophie Saunier, Ph.D., Team Leader, Institut des Maladies Génétiques
12:05 p.m. - 12:10 p.m. Questions
12:10 p.m. - 12:30 p.m. Advancing in the Research of Pediatric Autosomal Dominant PKD (ADPKD)
Djalila Mekahli, M.D., Ph.D., Professor, UZ Leuven, Belgium
12:30 p.m. - 12:35 p.m. Questions
12:35 p.m. - 1:05 p.m. Lunch Break
1:05 p.m. - 1:45 p.m. Trainee Short Communications
 

Session Chairs: Neera Dahl, M.D., Ph.D., Professor, Yale School of Medicine
Kenneth Hallows, M.D., Ph.D., Professor, University of Southern California
1:05 p.m. - 1:13 p.m. Human Organoid-on-a-Chip Model for Therapeutic Development in ARPKD
Navin Gupta, et al.
1:13 p.m. - 1:21 p.m. A Novel Organoid Model for Autosomal Dominant Polycystic Kidney Disease Based on Mouse Nephron Progenitor Cells (NPCs)
Yu Ishimoto, et al.
1:21 p.m. - 1:29 p.m. Xenopus Animal Models for Autosomal Polycystic Kidney Disease with Automated Deep Learning Analysis of Cystogenesis
Thomas Naert, et al.
1:29 p.m. - 1:37 p.m.

Identification of Novel Polycystin-Associated Cargo of Extracellular Vesicles (EVs) in Caenorhabditis Elegans
Inna Nikonorova, et al.
1:37 p.m. - 1:45 p.m.

Comparative PKD1 and PKD2 Missense Variant Profiling Aids Molecular Diagnoses Across the ADPKD Spectrum and Reveals Common Pathomechanisms
Cynthia J. Sieben, et al.
1:45 p.m. - 2:45 p.m. Technology Session: -Omics, Finding a Needle in a Haystack
 

Session Chairs: Whitney Besse, M.D., Assistant Professor, Yale School of Medicine
Brittany Lasseigne, Ph.D., Assistant Professor, The University of Alabama at Birmingham
1:45 p.m. - 2:05 p.m. Defining Cellular Complexity in Human ADPKD by Multimodal Single-cell Analysis
Benjamin Humphreys, M.D., Ph.D., Professor, Washington University in St. Louis
2:05 p.m. - 2:25 p.m. Reconciling Sample Size and Accuracy in Genetic Studies for Kidney Disease
Simone Sanna-Cherchi, M.D., Associate Professor, Columbia University
2:25 p.m. - 2:45 p.m. Panel Discussion
Luis Menezes, M.D., Ph.D.
Maria Irazabal Mira, M.D., Ph.D.
Kurt Zimmerman, Ph.D.
2:45 p.m. - 2:50 p.m. Break
2:50 p.m. - 3:20 p.m. Community Feedback-Critical Needs
  Breakout sessions will be hosted by each of the consortium divisions and focused on feedback from the community on what their critical needs are for new models and tools.
  Breakout 1: In Vitro Models, Chairs: Darren Wallace and Paul Welling
  Breakout 2: Animal Models, Chairs: C.J. Haycraft and Patricia Outeda Garcia
  Breakout 3: Clinical Resources, Chairs: Steve Seliger and Alan Yu
3:20 p.m. Adjournment

 

Welcome to Day 2
9:50 a.m. - 10:00 a.m. Welcome and Day 2 Introduction
Brad Yoder, Ph.D., UAHSF Endowed Chair in Biomedical Research, Professor and Chair of the Department of Cell, Developmental and Integrative Biology, The University of Alabama at Birmingham
10:00 a.m. - 11:15 a.m. Session 1: Cool New Tools
 

Session Chairs: Dagmar Wachten, Ph.D., Professor, University of Bonn, Germany
Ryuji Morizane, M.D., Ph.D., Assistant Professor, Harvard Medical School
10:00 a.m. - 10:20 a.m. PKD1 mRNA Cis-inhibition in ADPKD
Vishal Patel, M.D., Associate Professor, The University of Texas Southwestern Medical Center
10:20 a.m. - 10:25 a.m. Questions
10:25 a.m. - 10:45 a.m. Delivering Insights into Organ Homeostasis and Regeneration through In Vivo Genome-wide Screens
Kristin Knouse, M.D., Ph.D., Assistant Professor, Massachusetts Institute of Technology
10:45 a.m. - 10:50 a.m. Questions
10:50 a.m. - 11:10 a.m. Peptide-based Micelles for PKD
Eun Ji Chung, Ph.D., Associate Professor, University of Southern California
11:10 a.m. - 11:15 a.m. Questions
11:15 a.m. - 12:15 p.m. Session 2: Hot Takes in Energy Utilization
 

Session Chairs: Alessandra Boletta, Ph.D., Head of Unit, San Raffaele Scientific Institute
Laura Onuchic, M.D., Postdoctoral Associate, Yale School of Medicine
11:15 a.m. - 11:35 a.m. Listening in on the Conversation between Polycystins and Mitochondria
Michael Caplan, M.D., Ph.D., Professor, Yale School of Medicine
11:35 a.m. - 11:55 a.m. Harnessing NAD+ to Restore Energy Metabolism in Acute Kidney Injury
Samir Parikh, M.D., Professor, The University of Texas Southwestern Medical Center
11:55 a.m. - 12:15 p.m. Panel Discussion
Demetri Maxim, M.S.
Gregory Germino, M.D.
12:15 p.m. - 1:00 p.m. Lunch Break
1:00 p.m. - 3:00 p.m. Trainee Workshop: Meet with Successful Young Investigators
1:00 p.m. - 1:20 p.m.

Introduction-Meet with Our Panel Members
 

1:00 p.m. - 1:05 p.m.

 Christine Maric-Bilkan, Ph.D., Program Director, NIDDK
1:05 p.m. - 1:10 p.m. Katharina Hopp, Ph.D., Assistant Professor, University of Colorado
1:10 p.m. - 1:15 p.m. Ronak Lakhia, M.D., Assistant Professor, The University of Texas Southwestern Medical Center
1:15 p.m. - 1:20 p.m. Kurt Zimmerman, Ph.D., Assistant Professor, The University of Oklahoma
1:00 p.m. - 1:20 p.m. Introduction-Meet with Our Panel Members
1:20 p.m. - 2:50 p.m. Q & A session-Learn from the Experts
2:50 p.m. - 3:00 p.m. Closing Remarks
1:00 p.m. - 3:00 p.m. PKD-RRC Investigator Retreat
  Closed session meeting
3:00 p.m. Adjournment
Thank you for attending our Second Annual Virtual PKD-RRC Symposium!