Agenda

Speaker List Bios

Trainee Session Bios

All times are Eastern Daylight Time (EDT).

Welcome to Day 1
9:30 a.m. – 9:40 a.m. Welcome and Day 1 Introduction
Terry Watnick, M.D., Professor of Medicine, Joan B. and John H. Sadler Professor in Nephrology, and Principal Investigator, PKD RRC Coordinating Site, University of Maryland School of Medicine
Robert Star, M.D., Director, Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH)
9:40 a.m. – 10:00 a.m. The Patient Experience: Our Stories and Your Impact
Jullie Hoggan, PKD foundation volunteer and the facilitator of the Living Well with Kidney Disease Support group in Las Vegas
10:00 a.m.- 10:05 a.m. Questions
10:05 a.m. ‒ 11:20 a.m. Session 1: Ciliary Signaling
 

Session Chairs: Matthew Kavanaugh, M.D.- Ph.D., Physician Scientist Program, University of Kansas Medical Center
Gregory Pazour Ph.D., Professor, Program in Molecular Medicine, UMass Chan Medical School

10:05 a.m. – 10:25 a.m. Left, right and center: cilia and polycystin-2 as mechanotransducers during left-right axis development.
Shiaulou Yuan, Ph.D., Assistant Professor of Medicine, Harvard Medical School
10:25 a.m. – 10:30 a.m. Questions
10:30 a.m. – 10:50 a.m. ARL13B cilia localization and GEF activity in polycystic kidney disease
Robert E. Van Sciver, Ph.D., Postdoctoral Fellow, Emory University School of Medicine
10:50 a.m. – 10:55 a.m. Questions
10:55 a.m. – 11:00 a.m. Abstract Presentation

Role of Interferon-gamma in Cyst Formation After Acute Kidney Injury
Morgan E. Smith, University of Oklahoma Health Sciences Center
11:00 a.m. – 11:05 a.m. Questions
11:05 a.m. – 11:20 a.m. In Vivo Models subcommittee presentation and feedback session
Patricia Outeda Garcia, Ph.D., University of Maryland School of Medicine
11:20 a.m. – 11:30 a.m. Break
11:30 a.m. ‒ 1:15 p.m. Session 2: Is gene therapy for PKD on the horizon; Lessons learned from other inherited diseases.
 

Session Chairs: Vivek Bhalla, M.D., Associate Professor of Medicine, Stanford University
Anubhav Chakraborty, Ph.D., Candidate, The University of Kansas Medical Center
11:30 a.m. – 11:50 a.m. Learnings from neuromuscular disease gene therapies
Angela Lek, Ph.D., Vice President of Research, Muscular Dystrophy Association
11:50 a.m. – 11:55 a.m. Questions
11:55 a.m. – 12:15 p.m. The long and winding road to molecular cures for the first molecular disease.
John Tisdale, M.D., Branch Chief, Cellular and Molecular Therapeutics, NIH
12:15 p.m. – 12:20 p.m. Questions
12:20 p.m. – 12:40 p.m. Targeting the Kidneys with gene therapy
Matthew Wilson, M.D., Ph.D., Professor of Medicine, Vanderbilt University Medical Center
12:40 p.m. – 12:45 p.m. Questions
12:45 p.m. – 1:15 p.m. Lunch Break
1:15 p.m. – 2:50 p.m. Session 3: Next steps in identifying PKD therapies: Brainstorming
 

Session Chairs: Neera Dahl, M.D., Ph.D., Senior Associate Consultant, Mayo Clinic
Stephen Seliger, M.D., Associate Professor, University of Maryland School of Medicine

1:15 p.m. – 1:30 p.m. Therapy for PKD — Quo vadis?
Alan Yu, M.B., B. Chair., Professor of Medicine, The University of Kansas Medical Center
1:30 p.m. – 1:35 p.m. Questions
1:35 p.m. – 1:55 p.m. Brainstorming sessions – 4 breakout rooms (1 trainee session and 3 others)

Breakout Room Discussion Leaders:

Neera Dahl, M.D., Ph.D., Senior Associate Consultant, Mayo Clinic
Stephen Seliger, M.D., Associate Professor, University of Maryland School of Medicine
Vishal Patel, M.D., Professor, The University of Texas Southwestern Medical Center
Victoria Halperin-Kuhns, Ph.D., Research Associate, University of Maryland School of Medicine; Amanda Clark, Ph.D., Postdoctoral Fellow, The University of Alabama at Birmingham; and Anubhav Chakraborty, Ph.D. Candidate, The University of Kansa Medical Center
1:55 p.m. – 2:05 p.m. Break
2:05 p.m. – 2:25 p.m. Summary of Breakout sessions – 4 breakout rooms
2:25 p.m. – 2:40 p.m. Clinical subcommittee presentation feedback session
Stephen Seliger, M.D., Associate Professor, University of Maryland School of Medicine
2:40 p.m. – 2:45 p.m. Break
2:45 p.m. ‒ 4:05 p.m. Session 4: Tubuloids and Organoids
 

Session Chairs: Benjamin Freedman, Ph.D., Associate Professor, University of Washington
Isis Thomas, Ph.D. Candidate, Biomedical Science, The University of Alabama at Birmingham
2:45 p.m. – 3:05 p.m. Using Stem Cells to Explore Genetics Underlying Brain Disease
Kristen Brennand, Ph.D., Professor of Psychiatry, Yale University School of Medicine
3:05 p.m. – 3:10 p.m. Questions
3:10 p.m. – 3:30 p.m. Novel stem cell tools to model polycystic kidney disease
Zhongwei Li, Ph.D., Assistant Professor, Keck School of Medicine, University of Southern California
3:30 p.m. – 3:35 p.m. Questions
3:35 p.m. – 3:40 p.m. Abstract Presentation

Deciphering the impact of RAC1-SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models
Shohei Kuraoka, M.D., Ph.D., Postdoctoral Fellow Massachusetts General Hospital, Harvard Medical School
3:40 p.m. – 3:45 p.m. Questions
3:45 p.m. – 3:50 p.m. Abstract Presentation

Targeting ALDH1A1 Together With Nanoparticle Mediated Kidney Specific Immunotherapy Delays Cyst Growth in ADPKD
Alice Shasha Cheng, Ph.D., Mayo Clinic
3:50 p.m. – 3:55 p.m. Questions
3:55 p.m. – 4:00 p.m. Abstract Presentation

O-GlcNAcylation, a Modulator of Metabolism and Ciliogenesis, Promotes Autosomal Dominant Polycystic Kidney Disease (ADPKD) Progression
Matthew A. Kavanaugh, The University of Kansas Medical Center
4:00 p.m. – 4:05 p.m. Questions
4:05 p.m. Adjournment

 

Welcome to Day 2
9:50 a.m. – 10:00 a.m. Welcome and Day 2 Introduction
Brad Yoder, Ph.D., UAHSF Endowed Chair in Biomedical Research, Professor and Chair of the Department of Cell, Developmental and Integrative Biology, The University of Alabama at Birmingham
10:00 a.m. – 11:15 a.m. Session 5: New Techniques: Applications to Kidney Disease
 

Session Chairs: Britney Lasseigne, Ph.D., Assistant Professor, The University of Alabama at Birmingham
Victoria Halperin-Kuhns, Ph.D., Research Associate, University of Maryland School of Medicine

10:00 a.m. – 10:20 a.m. Closing the tech transfer gap: democratizable modular 3D microphysiological tissue models
Jason Gleghorn, Ph.D., Associate Professor, University of Delaware, Biomedical Engineering
10:20 a.m. – 10:25 a.m. Questions
10:25 a.m. – 10:45 a.m. Spatial analysis at cellular resolution to study human kidney disease
Tarek M. Ashkar (El-Achkar), MD, FASN, FACP, Professor of Medicine, Indiana University and the Roudebush VA Medical Center
10:45 a.m. – 10:50 a.m. Questions
10:50 a.m. – 11:10 a.m. 7β,27-Dihydroxycholesterol activates the heteromeric PC-1/2 polycystin complex
Kotdaji Ha, Ph.D., Research Associate, Department of Physiology at UCSF
11:10 a.m. – 11:15 a.m. Questions
11:15 a.m. – 11:20 a.m. Break
11:20 a.m. ‒ 12:35 p.m. Session 6: Polycystin Funtions
 

Session Chairs: Patricia Outeda Garcia, Ph.D., Assistant Professor, University of Maryland School of Medicine
Tony Maranto, M.D., Ph.D., Postdoctoral Fellow, University of Maryland School of Medicine
11:20 a.m. – 11:40 a.m. Cyst clonality and identity in Autosomal Dominant Polycystic Kidney Disease
Cristina Cebrian, Ph.D., Assistant Professor, Cincinnati Children’s Hospital Medical Center
11:40 a.m. – 11:45 a.m. Questions
11:45 a.m. – 12:05 p.m. Omics Approaches to PKD
Luis Menezes, M.D., Ph.D., Staff Scientist, Polycystic Kidney Disease Section, Kidney Diseases Branch, NIDDK, NIH
12:05 p.m. – 12:10 p.m. Questions
12:10 p.m. – 12:15 p.m. Abstract Presentation

Netrin-1 Deficiency Limits Cystogenesis in Autosomal Dominant PKD
Muthusamy Thangaraju, Ph.D., Associate Professor, Medical College Georgia, Augusta
12:15 p.m. – 12:20 p.m. Questions
12:20 p.m. – 12:35 p.m. Molecular subcommittee presentation and feedback session
Feng Qian, Ph.D., University of Maryland School of Medicine
12:35 p.m. – 1:05 p.m. Lunch Break
1:05 p.m. – 2:15 p.m. Session 7: Mechanisms of Cytogenesis
 

Session Chairs: Amanda D. Clark, Ph.D., Postdoctoral Fellow, The University of Alabama at Birmingham
Balaji Subramanian, Ph.D., Assistant Professor of Medicine, Beth Israel Deaconess Medical Center
1:05 p.m. – 1:25 p.m. Physiologic and Pathologic Tubule remodeling
Lloyd Cantley, M.D., Professor of Medicine, Yale School of Medicine
1:25 p.m. – 1:30 p.m. Questions
1:30 p.m. – 1:50 p.m. Modulation of hypomorphic polycystin-1 species in vivo ameliorates ADPKD progression
Sorin Fedeles, Ph.D., MBA, Executive Director, Polycystic Kidney Disease Outcomes Consortium (PKDOC), Adjunct Assistant Professor, Yale School of Medicine
1:50 p.m. – 1:55 p.m. Questions
1:55 p.m. – 2:00 p.m. Abstract Presentation

CFTR Based Therapy for Autosomal Recessive Polycystic Kidney Disease
Cristian Ciobanu, M.D., Johns Hopkins University, School of Medicine
2:00 p.m. – 2:05 p.m. Questions
2:05 p.m. – 2:10 p.m. Abstract Presentation

Role of Renal Nerves in a Preclinical Model of Advanced Autosomal Recessive Polycystic Kidney Disease
Madeline M. Gauthier, University of Arizona Health Sciences Center
2:10 p.m. – 2:15 p.m. Questions
2:15 p.m. – 2:30 p.m. Cell Models subcommittee presentation and feedback session
Paul Welling, M.D., Professor of Medicine, Ph.D.
2:30 p.m. Adjournment Thank you for attending our Third Annual Virtual PKD-RRC Symposium!

 

Day 2 (continued)
2:30 p.m. – 4:30 p.m. Trainee Workshop: Meet with Successful Young Investigators
 

Session Chairs: Victoria Halperin-Kuhns, Ph.D., Research Associate, University of Maryland School of Medicine
Amanda Clark, Ph.D., Postdoctoral Fellow, The University of Alabama at Birmingham
Anubhav Chakraborty, Ph.D. candidate, The University of Kansa Medical Center

2:30 p.m. – 2:40 p.m. Science is a Team Sport: The Art of Crafting (and Maintaining!) Healthy Training Environments
Laurence Boitet, Ph.D., University of Alabama at Birmingham
2:40 p.m. – 2:45 p.m. Questions
2:45 p.m. – 2:55 p.m. PKD Foundation Research Funding and Collaborative Opportunities
Elise Hoover, MPH, Vice President of Research Programs, PKD Foundation
2:55 p.m. – 3:00 p.m. Questions
3:00 p.m. – 3:10 p.m NIH Funding Opportunities for Trainees
Christine Maric-Bilkan, Program Officer, Division of Kidney, Urologic and Hematologic diseases, NIDDK/NIH
3:10 p.m. – 3:15 p.m. Questions
3:15 p.m. – 3:20 p.m. Break
3:20 p.m. - 3:30 p.m. Pivoting to PKD: How Training in Kidney Research Changed my Career Trajectory
Eryn Dixon, Ph.D., U.S. Food & Drug Administration
"Eryn Dixon is participating in her personal capacity."
3:30 p.m. – 3:35 p.m. Questions
3:35 p.m. – 3:45 p.m. My Transition From an Academic to a Biotech Career: Key Factors to Consider
Rachel Gallagher, Ph.D., Director of Biology, 4:59 NewCo
3:45 p.m. – 3:50 p.m. Questions
3:50 p.m. – 4:30 p.m. Panel Discussion with Speakers with Career Advice
4:30 p.m. Adjournment