Agenda

Welcome to Day 1
9:30 a.m. – 9:35 a.m. Welcome and Day 1 Introduction
Terry Watnick, M.D., Professor of Medicine, Joan B. and John H. Sadler Professor in Nephrology,
and Principal Investigator, PKD RRC Coordinating Site, University of Maryland School of Medicine
9:35 a.m. – 10:00 a.m. The Patient Experience: Our Stories and Your Impact
PEG
10:00 a.m. ‒ 11:15 a.m. Session 1: GLIS2—A Player in Polycystin Signaling and PKD Therapy
 

Session Chairs: Dorien Peters, Ph.D., Professor of Human Genetics, Leiden University Medical Center
Hyun Jun Jung, Ph.D., Instructor in Medicine, The Johns Hopkins University School of Medicine

10:00 a.m. – 10:25 a.m. Roles of GLIS2 and GLIS3 in Normal Kidney and Cystic Kidney Disease
Anton M. Jetten, Ph.D., Deputy Chief of the Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, NIH
10:25 a.m. – 10:30 a.m. Questions
10:30 a.m. – 10:55 a.m. Cilia Dependent Effectors of Polycystin Signaling
Stefan Somlo, M.D., C.N.H. Long Professor of Internal Medicine and Professor of Genetics, Yale School of Medicine
10:55 a.m. – 11:00 a.m. Questions
11:00 a.m. – 11:10 a.m. Abstract Presentation
Title: TBA
Name
11:10 a.m. – 11:15 a.m. Questions
11:15 a.m. – 11:30 a.m. Break
11:30 a.m. ‒ 12:30 p.m. Session 2: From Data to Discovery—Exploring Multidisciplinary Approaches in Genomics
 

Session Chairs: Vishal D. Patel, M.D., Professor, The University of Texas Southwestern Medical Center
Yoshiharu Muto, M.D., Ph.D., Assistant Professor, The University of Texas Southwestern Medical Center

11:30 a.m. – 11:55 a.m. Mapping Diversity and Development in the Mammalian Kidney Through Spatial Transcriptomics
Andrew P. McMahon, Ph.D., FRS, Research Professor of Biology and Biological Engineering, Merkin Institute for Translational Research, California Institute of Technology
11:55 a.m. – 12:00 p.m. Questions
12:00 p.m. – 12:25 p.m. Discovering Mechanisms of Human Kidney Disease From Polygenic Kidney Disease Loci
Gabriel B. Loeb, M.D., Ph.D., Assistant Professor, University of California, San Francisco (UCSF)
12:25 p.m. – 12:30 p.m. Questions
12:30 p.m. – 1:15 p.m. Lunch Break
1:15 p.m. – 2:20 p.m. Session 3: Consortium Overview—A Five-Year Review
 

Session Chairs: Brad Yoder, Ph.D., UAHSF Endowed Chair in Biomedical Research, Professor and Chair of the Department of Cell, Developmental and Integrative Biology, The University of Alabama at Birmingham
Terry Watnick, M.D., Professor of Medicine, Joan B. and John H. Sadler Professor in Nephrology, and Principal Investigator, PKD RRC Coordinating Site, University of Maryland School of Medicine

1:15 p.m. – 1:25 p.m. Subcommittee 1 – Cell, Owen M. Woodward, Ph.D., Associate Professor of Physiology and Medicine, University of Maryland Baltimore
1:25 p.m. – 1:35 p.m. Subcommittee 2 – Clinical, Stephen Seliger, M.D., M.S., Associate Professor of Medicine, University of Maryland Baltimore
1:35 p.m. – 1:45 p.m. Subcommittee 3 – In Vivo, Courtney "CJ" Haycraft, Ph.D., Associate Director, Transgenic and Genetically Engineered Models Core, University of Alabama at Birmingham
1:45 p.m. – 1:55 p.m. Subcommittee 4 – Molecular, Feng Qian, Ph.D., Professor of Medicine, University of Maryland Baltimore
1:55 p.m. – 2:05 p.m. Subcommittee 5 – Preclinical Assessment, Michal Mrug, M.D., Ph.D., Professor of Medicine, University of Alabama at Birmingham
2:05 p.m. – 2:20 p.m. Question and Answer Session
2:20 p.m. – 2:30 p.m. Break
2:30 p.m. ‒ 4:15 p.m. Session 4: Clinical Session
 

Session Chairs: Valeriu Cebotaru, M.D., Associate Professor, University of Maryland School of Medicine
Ashima Gulati, M.D., Ph.D., Assistant Professor of Pediatrics and Genomics and Precision Medicine, Children's Hospital of Philadelphia

2:30 p.m. – 2:55 p.m. Targeting Adiposity and Caloric Restriction in ADPKD
Kristen Nowak, Ph.D., Associate Professor, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus
2:55 p.m. – 3:00 p.m. Questions
3:00 p.m. – 3:25 p.m. Evidence for Health Disparities in the Management of Autosomal Dominant Polycystic Kidney Disease in the United States
Arlene Chapman, M.D., Professor of Medicine and Chief, Section of Nephrology, The University of Chicago
3:25 p.m. – 3:30 p.m. Questions
3:30 p.m. – 3:55 p.m. ARPKD - Current Clinical Perspectives
Kathrin Burgmaier, M.D., Professor, Division of Pediatric Nephrology, Immunology, and Hypertension, University of Cologne
3:55 p.m. – 4:00 p.m. Questions
4:00 p.m. – 4:10 p.m. Abstract Presentation
Title TBA
Name
4:10 p.m. – 4:15 p.m. Questions
4:15 p.m. Adjournment

 

Welcome to Day 2
9:25 a.m. – 9:30 a.m. Welcome and Day 2 Introduction
Brad Yoder, Ph.D., UAHSF Endowed Chair in Biomedical Research, Professor and Chair of the Department of Cell, Developmental and Integrative Biology, The University of Alabama at Birmingham
9:30 a.m. – 11:15 a.m. Session 1: Therapeutic Targets in PKD
 

Session Chairs: Robin Maser, Ph.D., Professor, Clinical Laboratory Sciences, The University of Kansas Medical Center
Duuamene (Mene) Nyimanu, Postdoctoral Fellow, The University of Kansas Medical Center

9:30 a.m. – 9:55 a.m. Reconstructing Tissue Microenvironment to Better Emulate Polycystic Kidney Disease
Yun Xia, Ph.D., Assistant Professor, Provost's Chair in Stem Cell Biology, Nanyang Technological University
9:55 a.m. – 10:00 a.m. Questions
10:00 a.m. – 10:25 a.m. Addressing the Therapeutic Potential of Bempedoic Acid in PKD: From Pre-Clinical Work to the BEAT-PKD Clinical Trial
Nuria Pastor-Soler, M.D., Ph.D., Associate Professor of Medicine, Associate Vice Chair for Faculty Development, USC
10:25 a.m. – 10:30 a.m. Questions
10:30 a.m. – 10:55 a.m. Discovery of the Effect of Caloric Restriction in ADPKD Leading to the PAPP-A Story
Eduardo Chini, M.D., Ph.D., Anesthesiologist, Mayo Clinic
10:55 a.m. – 11:00 a.m. Questions
11:00 a.m. – 11:10 a.m. Abstract Presentation
Title: TBA
Name
11:10 a.m. – 11:15 a.m. Questions
11:15 a.m. – 11:30 a.m. Break
11:30 a.m. ‒ 12:45 p.m. Session 2: Advances in Other Renal Cystic Diseases
 

Session Chairs: Katharina Hopp, Ph.D., Associate Professor, University of Colorado Anschutz Medical Campus
Kotaji Ha, Ph.D., Postdoctoral Researcher, Department of Physiology, UCSF
11:30 a.m. – 11:55 a.m. The Role of the Co-Chaperone DNAJB11 In ADPKD: Molecular Mechanisms and Cellular Origin of Cyst Formation
Michael Köttgen, Ph.D., Professor of Nephrology, University Medical Center – University of Freiburg
11:55 a.m. – 12:00 p.m. Questions
12:00 p.m. – 12:25 p.m. The Role of IFT Proteins in Monoallelic Polycystic Kidney Disease
Peter Harris, Ph.D., Professor of Cellular Biology, Mayo Clinic
12:25 p.m. – 12:30 p.m. Questions
12:30 p.m. – 12:40 p.m. Abstract Presentation
Title: TBA
Name
12:40 p.m. – 12:45 p.m. Questions
12:45 p.m. – 1:30 p.m. Lunch Break
1:30 p.m. – 3:15 p.m. Session 3: Beyond the Kidney
 

Session Chairs: Francisco Altamirano, Ph.D., Assistant Professor, Houston Methodist Research Institute
Cheng (Jack) Song, Ph.D., Assistant Professor, The University of Alabama at Birmingham
1:30 p.m. – 1:55 p.m. Targeting a TGFβ-matrix-Integrin Axis Halts the Progression of Polycystic Liver Disease
Scott Waddell, Ph.D., CSO Postdoctoral Research Fellow, The University of Edinburgh
1:55 p.m. – 2:00 p.m. Questions
2:00 p.m. – 2:25 p.m. Sensing a Stretch: Cardiac Polycystins, Natriuretic Peptides and Hypertension
Ivana Y. Kuo, Ph.D., Assistant Professor, Department of Cell and Molecular Physiology, Loyola University Chicago
2:25 p.m. – 2:30 p.m. Questions
2:30 p.m. – 2:55 p.m. Polycystins Recruit Cargo to Distinct Ciliary Extracellular Vesicle Subtypes
Maureen Barr, Ph.D., Professor of Genetics, Rutgers University
2:55 p.m. – 3:00 p.m. Questions
3:00 p.m. – 3:10 p.m. Abstract Presentation
Title: TBA
Name
3:10 p.m. – 3:15 p.m. Questions
3:15 p.m. Adjournment—Thank you for attending our Annual Virtual PKD-RRC Symposium!
Trainee Workshop
3:15 p.m. – 4:35 p.m. Trainee Workshop: Meet with Successful Young Investigators
 

Session Chairs: Duuamene (Mene) Nyimanu, Postdoctoral Fellow, The University of Kansas Medical Center
Sreelakshmi Cherakara, M.S., Graduate Research Assistant, The University of Alabama at Birmingham
3:15 p.m. – 3:25 p.m. Crafting a Successful Research Statement
Whitney Besse, M.D., Assistant Professor, Department of Internal Medicine, Section of Nephrology, Yale School of Medicine
3:25 p.m. – 3:30 p.m. Questions
3:30 p.m. – 3:40 p.m. From Ph.D. to Start-Up: The Importance of Founder-Led Biotech in Career Planning
Demetri Maxim, M.S., Chief Executive Officer, Nephrogen
3:45 p.m. – 3:50 p.m. Questions
3:50 p.m. – 4:00 p.m. Transitioning from Ph.D. and Postdoc to a Research Career in Industry: Timing Is Everything—Choosing Between Academia and Industry Careers
Shamim Ahmad, Ph.D., Executive Director, Precigen
4:00 p.m. – 4:05 p.m. Questions
4:05 p.m. – 4:15 p.m. Building a Career in Medical Affairs
Cibele Pinto, Ph.D., Senior Director, Medical Strategy, Global Medical Affairs, Otsuka Pharmaceutical
4:15 p.m. – 4:20 p.m. Questions
4:20 p.m. – 4:30 p.m. Grants for Trainees in PKD
4:30 p.m. – 4:35 p.m. Questions
4:35 p.m. Adjournment
Thank you for attending our Trainee Workshop!