EPA New Approach Methods (NAMs) Tools Training Workshop

EPA is hosting an in-person New Approach Methods (NAMs) Tools Training Workshop in Durham, North Carolina, on April 24–25, 2024. This in-person workshop builds on the ongoing virtual NAMs Virtual Trainings and will give participants the opportunity to advance their knowledge on EPA NAMs tools through overview sessions, in-depth learning, interactions with tool and data owners, and tool-specific case studies. EPA NAMs tools featured in the workshop include:

Workshop Information

Location: EPA’s Research Triangle Park, North Carolina, campus (IN-PERSON ONLY, no virtual option is available; space is limited)
Dates: Wednesday, April 24, and Thursday, April 25, 2024
Times: 9:00 a.m.–5:30 p.m. both days
Cost: None

• Adverse Outcome Pathway (AOP)-Wiki : The primary repository of qualitative information for the international AOP development effort coordinated by the Organisation for Economic Co-operation and Development (OECD).
• Chemical Exposure (ChemExpo) Knowledgebase : An interactive tool for exploring and searching information on how chemicals are used in commerce and in consumer products.
• Cheminformatics Modules : Provides high-quality chemical structures, experimental and predicted physicochemical properties, environmental fate and transport information, and linked toxicity data.
• CompTox Chemicals Dashboard : Provides chemistry, toxicity, and exposure information for more than 1 million chemicals. This information includes physicochemical data, hazard data, and much more.
• Ecotoxicology (ECOTOX) Knowledgebase : A comprehensive database providing information on adverse effects of single chemical stressors to ecologically relevant aquatic and terrestrial species.
• Generalized Read-Across (GenRA) Tool : An algorithmic approach to permit objective and reproducible read-across predictions of in vivo toxicity and in vitro bioactivity.
• High-Throughput Toxicokinetics (httk) R Package : Uses human in vitro data to make predictions about the fate of chemicals in humans, rats, mice, dogs, and rabbits.
• Sequence Alignment to Predict Across-Species Susceptibility (SeqAPASS) Tool : A fast, online screening tool that allows researchers and regulators to extrapolate toxicity information across species.
• Toxicity Estimation Software Tool (TEST) : Easily estimate the toxicity of chemicals using Quantitative Structure Activity Relationships (QSARs) methodologies.
• Toxicity Forecasting (ToxCast) : Makes in vitro medium- and high-throughput screening assay data publicly available for prioritization and hazard characterization of thousands of chemicals.

Attendees will have an opportunity to get a sneak peek of the following tools:

• Non-Targeted Analysis (NTA) Web Application : A universal web-based tool to aid researchers in performing production-level non-targeted analysis.
• RapidTox: A suite of workflows designed to address targeted human health data needs in support of decision-making.